Drug–polymer–water interaction and its implication for the dissolution performance of amorphous solid dispersions Y Chen, C Liu, Z Chen, C Su, M Hageman, M Hussain, R Haskell, ... Molecular pharmaceutics 12 (2), 576-589, 2015 | 168 | 2015 |
Initial drug dissolution from amorphous solid dispersions controlled by polymer dissolution and drug-polymer interaction Y Chen, S Wang, S Wang, C Liu, C Su, M Hageman, M Hussain, ... Pharmaceutical research 33, 2445-2458, 2016 | 132 | 2016 |
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers J Cantley, X Ye, E Rousseau, T Januario, BD Hamman, CM Rose, ... Nature Communications 13 (1), 6814, 2022 | 75 | 2022 |
Sodium lauryl sulfate competitively interacts with HPMC-AS and consequently reduces oral bioavailability of posaconazole/HPMC-AS amorphous solid dispersion Y Chen, S Wang, S Wang, C Liu, C Su, M Hageman, M Hussain, ... Molecular pharmaceutics 13 (8), 2787-2795, 2016 | 73 | 2016 |
Moisture-induced amorphous phase separation of amorphous solid dispersions: molecular mechanism, microstructure, and its impact on dissolution performance H Chen, Y Pui, C Liu, Z Chen, CC Su, M Hageman, M Hussain, R Haskell, ... Journal of pharmaceutical sciences 107 (1), 317-326, 2018 | 70 | 2018 |
Targeted delivery of a poorly water-soluble compound to hair follicles using polymeric nanoparticle suspensions M Morgen, GW Lu, D Du, R Stehle, F Lembke, J Cervantes, S Ciotti, ... International journal of pharmaceutics 416 (1), 314-322, 2011 | 60 | 2011 |
Discovery of BMS-955176, a second generation HIV-1 maturation inhibitor with broad spectrum antiviral activity A Regueiro-Ren, Z Liu, Y Chen, N Sin, SY Sit, JJ Swidorski, J Chen, ... ACS Medicinal Chemistry Letters 7 (6), 568-572, 2016 | 55 | 2016 |
Investigations of protein structure with optical spectroscopy: bovine growth hormone HA Havel, RS Chao, RJ Haskell, TJ Thamann Analytical chemistry 61 (7), 642-650, 1989 | 55 | 1989 |
Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery M Morgen, A Saxena, XQ Chen, W Miller, R Nkansah, A Goodwin, J Cape, ... European Journal of Pharmaceutics and Biopharmaceutics 117, 212-223, 2017 | 52 | 2017 |
Characterization of submicron systems via optical methods RJ Haskell Journal of Pharmaceutical Sciences 87 (2), 125-129, 1998 | 52 | 1998 |
Centrally delivered BACE1 inhibitor activates microglia, and reverses amyloid pathology and cognitive deficit in aged Tg2576 mice DR Thakker, S Sankaranarayanan, MR Weatherspoon, J Harrison, ... Journal of Neuroscience 35 (17), 6931-6936, 2015 | 50 | 2015 |
Auditory duration discrimination in the parakeet (Melopsittacus undulatus). RJ Dooling, RJ Haskell The Journal of the Acoustical Society of America 63 (5), 1640-1642, 1978 | 47 | 1978 |
Application of a Mixture Experimental Design in the Optimization of a Self‐Emulsifying Formulation with a High Drug Load P Gao, MJ Witt, RJ Haskell, KM Zamora, JR Shifflett Pharmaceutical development and technology 9 (3), 301-309, 2005 | 45 | 2005 |
Site-directed mutagenesis to probe protein folding: evidence that the formation and aggregation of a bovine growth hormone folding intermediate are dissociable processes SR Lehrman, JL Tuls, HA Havel, RJ Haskell, SD Putnam, CSC Tomich Biochemistry 30 (23), 5777-5784, 1991 | 45 | 1991 |
Discovery of a hepatitis C virus NS5B replicase palm site allosteric inhibitor (BMS-929075) advanced to phase 1 clinical studies KS Yeung, BR Beno, K Parcella, JA Bender, KA Grant-Young, A Nickel, ... Journal of Medicinal Chemistry 60 (10), 4369-4385, 2017 | 35 | 2017 |
Physical characterization of nanoparticles RJ Haskell Nanoparticle Technology for Drug Delivery, 127-162, 2006 | 32 | 2006 |
Laboratory scale milling process RJ Haskell US Patent 6,814,319, 2004 | 31 | 2004 |
A Combination Turbidity and Supernatant Microplate Assay to Rank‐Order the Supersaturation Limits of Early Drug Candidates JS Morrison, MJ Nophsker, RJ Haskell Journal of pharmaceutical sciences 103 (10), 3022-3032, 2014 | 28 | 2014 |
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a … A Regueiro-Ren, JJ Swidorski, Z Liu, Y Chen, N Sin, SY Sit, J Chen, ... Journal of Medicinal Chemistry 61 (16), 7289-7313, 2018 | 25 | 2018 |
Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect TT Kararli, MJ Kontny, S Desai, MJ Hageman, RJ Haskell US Patent 7,172,769, 2007 | 25* | 2007 |