Arwen R Pearson
Arwen R Pearson
University of Hamburg
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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
S Günther, PYA Reinke, Y Fernández-García, J Lieske, TJ Lane, HM Ginn, ...
Science 372 (6542), 642-646, 2021
All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding
TL Foster, T Belyaeva, NJ Stonehouse, AR Pearson, M Harris
Journal of virology 84 (18), 9267-9277, 2010
MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis
Y Wang, ME Graichen, A Liu, AR Pearson, CM Wilmot, VL Davidson
Biochemistry 42 (24), 7318-7325, 2003
Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules
M Levantino, BA Yorke, DCF Monteiro, M Cammarata, AR Pearson
Current opinion in structural biology 35, 41-48, 2015
Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography
C Mueller, A Marx, SW Epp, Y Zhong, A Kuo, AR Balo, J Soman, F Schotte, ...
Structural Dynamics 2 (5), 2015
Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket
BH Muller, C Lamoure, MH Le Du, L Cattolico, E Lajeunesse, F Lemaître, ...
Chembiochem 2 (7‐8), 517-523, 2001
Nature of the ferryl heme in compounds I and II
A Gumiero, CL Metcalfe, AR Pearson, EL Raven, PCE Moody
Journal of biological chemistry 286 (2), 1260-1268, 2011
Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism
PG Stockley, R Twarock, SE Bakker, AM Barker, A Borodavka, ...
Journal of biological physics 39, 277-287, 2013
Complex interplay between epitope specificity and isotype dictates the biological activity of anti-human CD40 antibodies
X Yu, HTC Chan, CM Orr, O Dadas, SG Booth, LN Dahal, CA Penfold, ...
Cancer cell 33 (4), 664-675. e4, 2018
Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography
S Oghbaey, A Sarracini, HM Ginn, O Pare-Labrosse, A Kuo, A Marx, ...
Acta Crystallographica Section D: Structural Biology 72 (8), 944-955, 2016
Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase
BJ Johnson, J Cohen, RW Welford, AR Pearson, K Schulten, JP Klinman, ...
Journal of Biological Chemistry 282 (24), 17767-17776, 2007
Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation
AR Pearson, T De la Mora-Rey, ME Graichen, Y Wang, LH Jones, ...
Biochemistry 43 (18), 5494-5502, 2004
Liquid application method for time-resolved analyses by serial synchrotron crystallography
P Mehrabi, EC Schulz, M Agthe, S Horrell, G Bourenkov, D von Stetten, ...
Nature methods 16 (10), 979-982, 2019
Serial synchrotron crystallography for time-resolved structural biology
AR Pearson, P Mehrabi
Current Opinion in Structural Biology 65, 168-174, 2020
X-ray-based techniques to study the nano–bio interface
C Sanchez-Cano, RA Alvarez-Puebla, JM Abendroth, T Beck, R Blick, ...
ACS nano 15 (3), 3754-3807, 2021
Structure‐guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release
TL Foster, GS Thompson, AP Kalverda, J Kankanala, M Bentham, ...
Hepatology 59 (2), 408-422, 2014
MauG-dependent in vitro biosynthesis of tryptophan tryptophylquinone in methylamine dehydrogenase
Y Wang, X Li, LH Jones, AR Pearson, CM Wilmot, VL Davidson
Journal of the American Chemical Society 127 (23), 8258-8259, 2005
The Crystal Structure of Cytochrome P460 of Nitrosomonas europaea Reveals a Novel Cytochrome Fold and Heme−Protein Cross-link,
AR Pearson, BO Elmore, C Yang, JD Ferrara, AB Hooper, CM Wilmot
Biochemistry 46 (28), 8340-8349, 2007
Microspectrophotometry for structural enzymology
AR Pearson, A Mozzarelli, GL Rossi
Current Opinion in Structural Biology 14 (6), 656-662, 2004
Sequence-specific, RNA–protein interactions overcome electrostatic barriers preventing assembly of satellite tobacco necrosis virus coat protein
RJ Ford, AM Barker, SE Bakker, RH Coutts, NA Ranson, SEV Phillips, ...
Journal of molecular biology 425 (6), 1050-1064, 2013
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