| Comprehensive characterization of cancer driver genes and mutations MH Bailey, C Tokheim, E Porta-Pardo, S Sengupta, D Bertrand, ... Cell 173 (2), 371-385. e18, 2018 | 2392 | 2018 |
| An integrative model of cellular states, plasticity, and genetics for glioblastoma C Neftel, J Laffy, MG Filbin, T Hara, ME Shore, GJ Rahme, AR Richman, ... Cell 178 (4), 835-849. e21, 2019 | 2040 | 2019 |
| Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma I Tirosh, AS Venteicher, C Hebert, LE Escalante, AP Patel, K Yizhak, ... Nature 539 (7628), 309-313, 2016 | 1100 | 2016 |
| Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq AS Venteicher, I Tirosh, C Hebert, K Yizhak, C Neftel, MG Filbin, ... Science 355 (6332), eaai8478, 2017 | 934 | 2017 |
| Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq MG Filbin, I Tirosh, V Hovestadt, MKL Shaw, LE Escalante, ... Science 360 (6386), 331-335, 2018 | 620 | 2018 |
| GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas RG Majzner, S Ramakrishna, KW Yeom, S Patel, H Chinnasamy, ... Nature 603 (7903), 934-941, 2022 | 582 | 2022 |
| Resolving medulloblastoma cellular architecture by single-cell genomics V Hovestadt, KS Smith, L Bihannic, MG Filbin, MKL Shaw, A Baumgartner, ... Nature 572 (7767), 74-79, 2019 | 384 | 2019 |
| Stalled developmental programs at the root of pediatric brain tumors S Jessa, A Blanchet-Cohen, B Krug, M Vladoiu, M Coutelier, D Faury, ... Nature genetics 51 (12), 1702-1713, 2019 | 243 | 2019 |
| Developmental origins and emerging therapeutic opportunities for childhood cancer M Filbin, M Monje Nature medicine 25 (3), 367-376, 2019 | 199 | 2019 |
| Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma GL Lin, S Nagaraja, MG Filbin, ML Suvà, H Vogel, M Monje Acta neuropathologica communications 6, 1-12, 2018 | 173 | 2018 |
| Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG JN Anastas, BM Zee, JH Kalin, M Kim, R Guo, S Alexandrescu, MA Blanco, ... Cancer cell 36 (5), 528-544. e10, 2019 | 160 | 2019 |
| Histone variant and cell context determine H3K27M reprogramming of the enhancer landscape and oncogenic state S Nagaraja, MA Quezada, SM Gillespie, M Arzt, JJ Lennon, PJ Woo, ... Molecular cell 76 (6), 965-980. e12, 2019 | 150 | 2019 |
| Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities M Gruber Filbin, SK Dabral, MF Pazyra-Murphy, S Ramkissoon, AL Kung, ... Nature medicine 19 (11), 1518-1523, 2013 | 149 | 2013 |
| Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis CCL Chen, S Deshmukh, S Jessa, D Hadjadj, V Lisi, AF Andrade, D Faury, ... Cell 183 (6), 1617-1633. e22, 2020 | 142 | 2020 |
| Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma J Gojo, B Englinger, L Jiang, JM Hübner, MKL Shaw, OA Hack, ... Cancer cell 38 (1), 44-59. e9, 2020 | 135 | 2020 |
| Molecular and clinicopathologic features of gliomas harboring NTRK fusions M Torre, V Vasudevaraja, J Serrano, M DeLorenzo, S Malinowski, ... Acta Neuropathologica Communications 8, 1-14, 2020 | 109 | 2020 |
| The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location I Liu, L Jiang, ER Samuelsson, S Marco Salas, A Beck, OA Hack, D Jeong, ... Nature Genetics 54 (12), 1881-1894, 2022 | 105 | 2022 |
| Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors SH Ramkissoon, P Bandopadhayay, J Hwang, LA Ramkissoon, ... Neuro-oncology 19 (7), 986-996, 2017 | 96 | 2017 |
| Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways S Venneti, AR Kawakibi, S Ji, SM Waszak, SR Sweha, M Mota, M Pun, ... Cancer discovery 13 (11), 2370-2393, 2023 | 75 | 2023 |
| Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma N Manoharan, J Choi, C Chordas, MA Zimmerman, J Scully, J Clymer, ... Journal of Neuro-Oncology 149, 253-262, 2020 | 67 | 2020 |
Keith L. LigonAssociate Professor, Harvard Medical SchoolVerified email at dfci.harvard.edu
