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Paul E Brennan
Paul E Brennan
Verified email at cmd.ox.ac.uk - Homepage
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Cited by
Year
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8662015
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
P Brennan, JW Babbage, BMT Burgering, B Groner, K Reif, DA Cantrell
Immunity 7 (5), 679-689, 1997
5271997
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ...
Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013
5002013
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
3442014
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
YY Dong, ACW Pike, A Mackenzie, C McClenaghan, P Aryal, L Dong, ...
Science 347 (6227), 1256-1259, 2015
3332015
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains
S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ...
Cancer research 73 (11), 3336-3346, 2013
2982013
Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix
JP Aggleton, D McMackin, K Carpenter, J Hornak, N Kapur, S Halpin, ...
Brain 123 (4), 800-815, 2000
2792000
Rapid covalent-probe discovery by electrophile-fragment screening
E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ...
Journal of the American Chemical Society 141 (22), 8951-8968, 2019
2782019
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
A Hammitzsch, C Tallant, O Fedorov, A O’Mahony, PE Brennan, DA Hay, ...
Proceedings of the National Academy of Sciences 112 (34), 10768-10773, 2015
2652015
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ...
Journal of medicinal chemistry 55 (22), 9831-9837, 2012
2582012
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy
S Picaud, O Fedorov, A Thanasopoulou, K Leonards, K Jones, J Meier, ...
Cancer research 75 (23), 5106-5119, 2015
2532015
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
M Saitoh, N Pullen, P Brennan, D Cantrell, PB Dennis, G Thomas
Journal of Biological Chemistry 277 (22), 20104-20112, 2002
2292002
Progress in the development and application of small molecule inhibitors of bromodomain–acetyl-lysine interactions
DS Hewings, TPC Rooney, LE Jennings, DA Hay, CJ Schofield, ...
Journal of medicinal chemistry 55 (22), 9393-9413, 2012
2202012
LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor
PGK Clark, LCC Vieira, C Tallant, O Fedorov, DC Singleton, CM Rogers, ...
Angewandte Chemie 127 (21), 6315-6319, 2015
2172015
Recent progress in histone demethylase inhibitors
TE McAllister, KS England, RJ Hopkinson, PE Brennan, A Kawamura, ...
Journal of medicinal chemistry 59 (4), 1308-1329, 2016
1962016
Structural analysis of human KDM5B guides histone demethylase inhibitor development
C Johansson, S Velupillai, A Tumber, A Szykowska, ES Hookway, ...
Nature chemical biology 12 (7), 539-545, 2016
1892016
Fragment-based hit identification: thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ...
Drug Discovery Today 18 (23-24), 1221-1227, 2013
1872013
A genetics-led approach defines the drug target landscape of 30 immune-related traits
H Fang, H De Wolf, B Knezevic, KL Burnham, J Osgood, A Sanniti, ...
Nature genetics 51 (7), 1082-1091, 2019
1862019
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain
OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ...
Chemical science 7 (3), 2322-2330, 2016
1812016
p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes
P Brennan, JW Babbage, G Thomas, D Cantrell
Molecular and cellular biology 19 (7), 4729-4738, 1999
1811999
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