| Copper is required for oncogenic BRAF signalling and tumorigenesis DC Brady, MS Crowe, ML Turski, GA Hobbs, X Yao, A Chaikuad, S Knapp, ... Nature 509 (7501), 492-496, 2014 | 556 | 2014 |
| Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ... Journal of Biological Chemistry 288 (11), 7803-7814, 2013 | 309 | 2013 |
| The ins and outs of selective kinase inhibitor development S Müller, A Chaikuad, NS Gray, S Knapp Nature chemical biology 11 (11), 818-821, 2015 | 294 | 2015 |
| A new class of small molecule inhibitor of BMP signaling CE Sanvitale, G Kerr, A Chaikuad, MC Ramel, AH Mohedas, S Reichert, ... PloS one 8 (4), e62721, 2013 | 255 | 2013 |
| A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics A Chaikuad, E MC Tacconi, J Zimmer, Y Liang, NS Gray, M Tarsounas, ... Nature chemical biology 10 (10), 853-860, 2014 | 231 | 2014 |
| The cysteinome of protein kinases as a target in drug development A Chaikuad, P Koch, SA Laufer, S Knapp Angewandte Chemie International Edition 57 (16), 4372-4385, 2018 | 220 | 2018 |
| Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva A Chaikuad, I Alfano, G Kerr, CE Sanvitale, JH Boergermann, JT Triffitt, ... Journal of Biological Chemistry 287 (44), 36990-36998, 2012 | 204 | 2012 |
| Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B P Chen, A Chaikuad, P Bamborough, M Bantscheff, C Bountra, C Chung, ... Journal of medicinal chemistry 59 (4), 1410-1424, 2016 | 164 | 2016 |
| Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1 GF De Nicola, ED Martin, A Chaikuad, R Bassi, J Clark, L Martino, ... Nature structural & molecular biology 20 (10), 1182-1190, 2013 | 129 | 2013 |
| 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A H Falke, A Chaikuad, A Becker, N Loaëc, O Lozach, S Abu Jhaisha, ... Journal of medicinal chemistry 58 (7), 3131-3143, 2015 | 122 | 2015 |
| Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B L Drouin, S McGrath, LR Vidler, A Chaikuad, O Monteiro, C Tallant, ... Journal of medicinal chemistry 58 (5), 2553-2559, 2015 | 121 | 2015 |
| Selective JAK3 inhibitors with a covalent reversible binding mode targeting a new induced fit binding pocket M Forster, A Chaikuad, SM Bauer, J Holstein, MB Robers, CR Corona, ... Cell chemical biology 23 (11), 1335-1340, 2016 | 115 | 2016 |
| Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease J Batson, HD Toop, C Redondo, R Babaei-Jadidi, A Chaikuad, ... ACS chemical biology 12 (3), 825-832, 2017 | 103 | 2017 |
| Structural basis of intracellular TGF-β signaling: receptors and smads A Chaikuad, AN Bullock Cold Spring Harbor perspectives in biology 8 (11), a022111, 2016 | 101 | 2016 |
| Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain FM Ferguson, O Fedorov, A Chaikuad, M Philpott, JRC Muniz, I Felletar, ... Journal of medicinal chemistry 56 (24), 10183-10187, 2013 | 101 | 2013 |
| Discovery of a PCAF bromodomain chemical probe M Moustakim, PGK Clark, L Trulli, AL Fuentes de Arriba, MT Ehebauer, ... Angewandte Chemie 129 (3), 845-849, 2017 | 93 | 2017 |
| UDP-glucose dehydrogenase: structure and function of a potential drug target S Egger, A Chaikuad, KL Kavanagh, U Oppermann, B Nidetzky Biochemical Society Transactions 38 (5), 1378-1385, 2010 | 88 | 2010 |
| Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells Y Morozumi, F Boussouar, M Tan, A Chaikuad, M Jamshidikia, G Colak, ... Journal of molecular cell biology 8 (4), 349-362, 2016 | 84 | 2016 |
| Structure and mechanism of human UDP-glucose 6-dehydrogenase S Egger, A Chaikuad, KL Kavanagh, U Oppermann, B Nidetzky Journal of Biological Chemistry 286 (27), 23877-23887, 2011 | 83 | 2011 |
| Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action AE Fernández-Montalván, M Berger, B Kuropka, SJ Koo, V Badock, ... ACS chemical biology 12 (11), 2730-2736, 2017 | 82 | 2017 |
