James Holton
James Holton
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Femtosecond X-ray protein nanocrystallography
HN Chapman, P Fromme, A Barty, TA White, RA Kirian, A Aquila, ...
Nature 470 (7332), 73-77, 2011
Structures of the bacterial ribosome at 3.5 A resolution
BS Schuwirth, MA Borovinskaya, CW Hau, W Zhang, A Vila-Sanjurjo, ...
Science 310 (5749), 827-834, 2005
Accessing protein conformational ensembles using room-temperature X-ray crystallography
JS Fraser, H Van Den Bedem, AJ Samelson, PT Lang, JM Holton, ...
Proceedings of the National Academy of Sciences 108 (39), 16247-16252, 2011
An assessment of the resolution limitation due to radiation-damage in x-ray diffraction microscopy
MR Howells, T Beetz, HN Chapman, C Cui, JM Holton, CJ Jacobsen, ...
Journal of electron spectroscopy and related phenomena 170 (1-3), 4-12, 2009
Structures of the intermediates of Kok’s photosynthetic water oxidation clock
J Kern, R Chatterjee, ID Young, FD Fuller, L Lassalle, M Ibrahim, S Gul, ...
Nature 563 (7731), 421-425, 2018
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling
MA Borovinskaya, RD Pai, W Zhang, BS Schuwirth, JM Holton, ...
Nature structural & molecular biology 14 (8), 727-732, 2007
Large language models generate functional protein sequences across diverse families
A Madani, B Krause, ER Greene, S Subramanian, BP Mohr, JM Holton, ...
Nature Biotechnology 41 (8), 1099-1106, 2023
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden, MS Podgorski, DT Huang, DW Miller, RJ Howard, DL Minor, ...
Molecular cell 12 (6), 1427-1437, 2003
A beginner's guide to radiation damage
JM Holton
Journal of synchrotron radiation 16 (2), 133-142, 2009
Ubiquitin recognition by the human TSG101 protein
WI Sundquist, HL Schubert, BN Kelly, GC Hill, JM Holton, CP Hill
Molecular cell 13 (6), 783-789, 2004
Time-resolved protein nanocrystallography using an X-ray free-electron laser
A Aquila, MS Hunter, RB Doak, RA Kirian, P Fromme, TA White, ...
Optics express 20 (3), 2706-2716, 2012
Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity
DT Huang, HW Hunt, M Zhuang, MD Ohi, JM Holton, BA Schulman
Nature 445 (7126), 394-398, 2007
Structural and mechanistic studies of VPS4 proteins
A Scott, HY Chung, M Gonciarz‐Swiatek, GC Hill, FG Whitby, J Gaspar, ...
The EMBO journal 24 (20), 3658-3669, 2005
Automated protein crystal structure determination using ELVES
J Holton, T Alber
Proceedings of the National Academy of Sciences 101 (6), 1537-1542, 2004
Crystallographic analysis of CD40 recognition and signaling by human TRAF2
SM McWhirter, SS Pullen, JM Holton, JJ Crute, MR Kehry, T Alber
Proceedings of the National Academy of Sciences 96 (15), 8408-8413, 1999
Femtosecond protein nanocrystallography—data analysis methods
RA Kirian, X Wang, U Weierstall, KE Schmidt, JCH Spence, M Hunter, ...
Optics express 18 (6), 5713-5723, 2010
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source
S Classen, GL Hura, JM Holton, RP Rambo, I Rodic, PJ McGuire, K Dyer, ...
Journal of applied crystallography 46 (1), 1-13, 2013
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1
DT Huang, A Paydar, M Zhuang, MB Waddell, JM Holton, BA Schulman
Molecular cell 17 (3), 341-350, 2005
The minimum crystal size needed for a complete diffraction data set
JM Holton, KA Frankel
Acta Crystallographica Section D: Biological Crystallography 66 (4), 393-408, 2010
Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser
L Lomb, TRM Barends, S Kassemeyer, A Aquila, SW Epp, B Erk, L Foucar, ...
Physical Review B 84 (21), 214111, 2011
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