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Sebastian Mathea
Sebastian Mathea
Unknown affiliation
Verified email at pharmchem.uni-frankfurt.de - Homepage
Title
Cited by
Cited by
Year
Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
CK Deniston, J Salogiannis, S Mathea, DM Snead, I Lahiri, ...
Nature 588 (7837), 344-349, 2020
2022020
Melanin Is Not Required for Turgor Generation but Enhances Cell-Wall Rigidity in Appressoria of the Corn Pathogen Colletotrichum graminicola
N Ludwig, M Löhrer, M Hempel, S Mathea, I Schliebner, M Menzel, ...
Molecular Plant-Microbe Interactions 27 (4), 315-327, 2014
1092014
Isoform-specific inhibition of cyclophilins
S Daum, M Schumann, S Mathea, T Aumüller, MA Balsley, SL Constant, ...
Biochemistry 48 (26), 6268-6277, 2009
892009
Sfp-type 4′-phosphopantetheinyl transferase is indispensable for fungal pathogenicity
R Horbach, A Graf, F Weihmann, L Antelo, S Mathea, JC Liermann, ...
The Plant Cell 21 (10), 3379-3396, 2009
832009
Structural insights into pseudokinase domains of receptor tyrosine kinases
JB Sheetz, S Mathea, H Karvonen, K Malhotra, D Chatterjee, W Niininen, ...
Molecular cell 79 (3), 390-405. e7, 2020
782020
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level
D Coutandin, C Osterburg, RK Srivastav, M Sumyk, S Kehrloesser, ...
Elife 5, e13909, 2016
672016
Modulating androgen receptor-driven transcription in prostate cancer with selective CDK9 inhibitors
A Richters, SK Doyle, DB Freeman, C Lee, BS Leifer, S Jagannathan, ...
Cell chemical biology 28 (2), 134-147. e14, 2021
642021
Comprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
A Pinto-Fernández, S Davis, AB Schofield, HC Scott, P Zhang, E Salah, ...
Frontiers in chemistry 7, 592, 2019
562019
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2
SH Schmidt, JH Weng, PC Aoto, D Boassa, S Mathea, S Silletti, J Hu, ...
Proceedings of the National Academy of Sciences 118 (23), e2100844118, 2021
512021
A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin
K Ernst, M Liebscher, S Mathea, A Granzhan, J Schmid, MR Popoff, ...
Scientific reports 6 (1), 20301, 2016
482016
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
AU Malik, A Karapetsas, RS Nirujogi, S Mathea, D Chatterjee, P Pal, P Lis, ...
Biochemical Journal 478 (3), 553-578, 2021
422021
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization
J Gebel, LM Luh, D Coutandin, C Osterburg, F Löhr, B Schäfer, ...
Cell Death & Differentiation 23 (12), 1930-1940, 2016
402016
Pan-SMARCA/PB1 bromodomain inhibitors and their role in regulating adipogenesis
M Wanior, F Preuss, X Ni, A Krämer, S Mathea, T Göbel, ...
Journal of medicinal chemistry 63 (23), 14680-14699, 2020
272020
Quantitative characterization of bivalent probes for a dual bromodomain protein, transcription initiation factor TFIID subunit 1
JL Suh, B Watts, JI Stuckey, JL Norris-Drouin, SH Cholensky, BM Dickson, ...
Biochemistry 57 (14), 2140-2149, 2018
242018
Kinase domain is a dynamic hub for driving LRRK2 allostery
SS Taylor, P Kaila-Sharma, JH Weng, P Aoto, SH Schmidt, S Knapp, ...
Frontiers in molecular neuroscience 13, 538219, 2020
232020
Nucleotide binding, evolutionary insights, and interaction partners of the pseudokinase Unc-51-like kinase 4
F Preuss, D Chatterjee, S Mathea, S Shrestha, J St-Germain, M Saha, ...
Structure 28 (11), 1184-1196. e6, 2020
222020
Structure of the human protein kinase ZAK in complex with vemurafenib
S Mathea, KR Abdul Azeez, E Salah, C Tallant, F Wolfreys, R Konietzny, ...
ACS chemical biology 11 (6), 1595-1602, 2016
222016
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains
JH Weng, PC Aoto, R Lorenz, J Wu, SH Schmidt, JT Manschwetus, ...
PLoS biology 20 (2), e3001427, 2022
212022
Identification of pyrimidine-based lead compounds for understudied kinases implicated in driving neurodegeneration
DH Drewry, JK Annor-Gyamfi, CI Wells, JE Pickett, V Dederer, F Preuss, ...
Journal of Medicinal Chemistry 65 (2), 1313-1328, 2021
212021
Suppression of EGFR autophosphorylation by FKBP12
S Mathea, S Li, A Schierhorn, G Jahreis, C Schiene-Fischer
Biochemistry 50 (50), 10844-10850, 2011
192011
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