Rui Sousa
Rui Sousa
U. of TX Health Sci. Ctr.
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Cited by
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Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution
R Sousa, YJ Chung, JP Rose, BC Wang
Nature 364 (6438), 593-599, 1993
Structural basis of interdomain communication in the Hsc70 chaperone
J Jiang, K Prasad, EM Lafer, R Sousa
Molecular cell 20 (4), 513-524, 2005
A mutant T7 RNA polymerase as a DNA polymerase.
R Sousa, R Padilla
The EMBO journal 14 (18), 4609-4621, 1995
Structural basis of J cochaperone binding and regulation of Hsp70
J Jiang, EG Maes, AB Taylor, L Wang, AP Hinck, EM Lafer, R Sousa
Molecular cell 28 (3), 422-433, 2007
Structure of the Hsp110: Hsc70 nucleotide exchange machine
JP Schuermann, J Jiang, J Cuellar, O Llorca, L Wang, LE Gimenez, S Jin, ...
Molecular cell 31 (2), 232-243, 2008
A model for the mechanism of polymerase translocation
R Guajardo, R Sousa
Journal of molecular biology 265 (1), 8-19, 1997
A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non‐canonical NTPs
R Padilla, R Sousa
Nucleic acids research 30 (24), e138-e138, 2002
Structural and mechanistic relationships between nucleic acid polymerases
R Sousa
Trends in biochemical sciences 21 (5), 186-190, 1996
Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
R Sousa, JJ Jendrisak
US Patent 5,849,546, 1998
Use of glycerol, polyols and other protein structure stabilizing agents in protein crystallization
R Sousa
Acta Crystallographica Section D: Biological Crystallography 51 (3), 271-277, 1995
Efficient synthesis of nucleic acids heavily modified with non-canonical ribose 2′-groups using a mutant T7 RNA polymerase (RNAP)
R Padilla, R Sousa
Nucleic acids research 27 (6), 1561-1563, 1999
T7 RNA polymerase
R Sousa, S Mukherjee, M Kivie
Progress in nucleic acid research and molecular biology 73 (73), 1-41, 2003
In Situ Hybridization Mapping of Glucocorticoid Receptor Messenger Ribonucleic Acid in Rat Brain
RJ Sousa, NH Tannery, EM Lafer
Molecular Endocrinology 3 (3), 481-494, 1989
Mechanism of ribose 2 ‘-group discrimination by an RNA polymerase
Y Huang, F Eckstein, R Padilla, R Sousa
Biochemistry 36 (27), 8231-8242, 1997
Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1
L Shaner, R Sousa, KA Morano
Biochemistry 45 (50), 15075-15084, 2006
Mutations in T7 RNA polymerase that support the proposal for a common polymerase active site structure.
G Bonner, D Patra, EM Lafer, R Sousa
The EMBO journal 11 (10), 3767-3775, 1992
Misincorporation by wild-type and mutant T7 RNA polymerases: identification of interactions that reduce misincorporation rates by stabilizing the catalytically incompetent open …
J Huang, LG Brieba, R Sousa
Biochemistry 39 (38), 11571-11580, 2000
The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin
J Cuéllar, J Martín-Benito, SHW Scheres, R Sousa, F Moro, ...
Nature structural & molecular biology 15 (8), 858-864, 2008
Model for the mechanism of bacteriophage T7 RNAP transcription initiation and termination
R Sousa, D Patra, EM Lafer
Journal of molecular biology 224 (2), 319-334, 1992
Synthesis and applications of RNAs with position-selective labelling and mosaic composition
Y Liu, E Holmstrom, J Zhang, P Yu, J Wang, MA Dyba, D Chen, J Ying, ...
Nature 522 (7556), 368-372, 2015
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